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Wednesday, February 29, 2012
How Dow 30 have performed since last 13,000 close (AP)
[unable to retrieve full-text content]AP - How the 30 stocks in the Dow Jones industrial average have performed since May 19, 2008, the first time the average closed above 13,000:
Tuesday, February 28, 2012
Search Engine Marketing Services for Business Owners ? Article ...
[unable to retrieve full-text content]Online marketing and online advertising, local internet marketing, SEO, social media marketing, PPC marketing and PPC advertising, search engine marketing , mobile advertising and mobile marketing,online reputation and ...
Source: http://list-of-directory.com/computers/search-engine-marketing-services-for-business-owners/
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The Easiest Medicine Ball Programs | New Health and Fitness
New Health And Fitness.Org - Health Information You Can Use
If you want the best tool to develop your core and your abs, then you have to look to the almighty medicine ball. They are just the best tool because they allow you to work out with a full range of motion. Plus most of the exercises that you do with them involve your abs in one way or another.
One of the most common ways to do this is to pass the ball with someone else. By throwing the ball back and forth, you work on your throwing and catching muscles more naturally.
But with something like a medicine ball, you can move them around more naturally, hitting more muscle groups and improving your body?s actual strength. That?s what you have to do if you want to get good at sports.
Plus it also allows you to target the core more completely. That means workouts that target the way your core will be moving when playing a sport, so that you can get a heck of a lot stronger as well.
The reason that medicine balls are so ideal, is because they allow you to perform a lot of sport types of motions when you?re working out . They don?t just have to be lifted like weights would.
First off, you?ve got to start small. It?s going to be a rude awakening when you?re lifting weights, and you?ve got to be prepared if you commonly have only used weight machines for the muscles you didn?t know about.
For example, one of the best full body movements are the wood choppers. They are going to work your arms, your legs, as well as your back and your core. They make your entire body stronger from top to bottom.
That?s why you don?t want to strain yourself, and you should always start small. Medicine balls come in a variety of different sized for a reason. Start small, and then work your way up to the big ones later on.
Check out out extra of this writer?s creating about http://penisadvantageresults.com.
Source: http://newhealthandfitness.org/2012/02/26/the-easiest-medicine-ball-programs/
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Monday, February 27, 2012
Managed Computing Business - IT Marylebone Solutions ...
You will discover quite a few causes why a enterprise need to seriously look at hiring managed IT Marylebone?services to assist move their business forward. Devoid of a maximized workflow and optimally functioning technology, a corporation could shed useful facts through challenges that may possibly arise. Regardless of what size organization you?re coping with, be sure you contemplate acquiring a service that can assist you with the heavy lifting. Unless you?re going to start an in-house IT department, you?ll have to contemplate enhancing your organization with an outsourced tech team. There are actually three significant causes why deciding upon an outside IT company is a great choice.
Threat Management ? If you hire a tech organization to handle personal computer assistance services, you may feel confident in your workplace technologies and focus on enterprise operations. As opposed to hiring an in-house team that would take up space and resources inside your location of small business, you will instead minimize the risks involved with hiring, insurance and a lot far more by simply finding an IT service that is separate from your small business place.
Infrastructure Control ? If you are coping with computer system networking, technology, internet sites and considerably more, you?ll should have full control more than updating and main processes that make them function. This is specifically true if you are operating a shopping cart computer software on your web page. With no manage, you won?t be moving forward with infrastructure. As an example, if the network goes down at any offered moment, you will end up having peace of mind due to the fact you can get your internet site back in operating order right away, as an alternative to getting to wait for the tech team to arrive at the workplace.
Much less Operate, Much more Efficiency ? The main reason why you may need to have a service of this sort is mainly because it will mean less perform within the long-term. Your tasks will not be related to technologies, and rather your enterprise can move forward with relative ease. In-house staff generally occasions have much more work to complete than just concentrate on the managing of technological advances, which can at times bottleneck specific aspects of infrastructure. By removing that element, and finding a service, you might ensure that small business is moving forward at all hours from the day as well as night if require be.
The aforementioned factors are just a number of examples to consider when deciding whether or not to hire an IT company for computer system support services. Services are varied and you will find a lot far more arguments both for and against hiring outsourced IT providers. The above are just a few causes that ought to help maintain you motivated in hiring a team that is currently operating in technology, as an alternative to wanting to make a ?dream team? for yourself. You could devote month following month attempting to figure out who to decide on to come on board and assist along with your tech wants, or you may let the professionals deal with your demands with relative ease. By hiring an outside firm, you may also be saving a tremendous level of income that would otherwise be spent on an in-house IT Marylebone?department. The long term savings will trump the costs which you would need to invest in finding and forming a right team to manage all tech help. Outside firms have expertise and staff to handle any and all demands that arise, so your company is covered.
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Source: http://www.itservices-london.com/it-marylebone-2011201212736/
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Sunday, February 26, 2012
Protective Soft Silicone Case for Samsung Galaxy Nexus i9250 / Nexus Prime - Black
? 
Typically ships in 4 to 7 days* (7 to 10 during new year season)
??
Worldwide Free Shipping
- Material: Soft Silicone
- Protects your cell phone from scratches, dust and shock
- Suitable for Samsung Galaxy Nexus i9250 / Nexus Prime To enable volume discounts on this site, use coupon code: BULKRATE during checkout. You will see a discount applied at the bottom of the shopping cart. Competitive pricing is available. Contact us for details.
What is Bulk Rate? BulkRate is a semi-wholesale system
with items priced separately from retail. When you use bulk rates, a flat $1.70
registered air mail fee will automatically be added to your cart to ensure delivery
of package. While BulkRate's intention is to offer cheaper prices when you buy in
bulk, because it is priced separately it on occassions show a higher than retail
price. That's why we ask you to enter BULKRATE as a coupon code to manually activate
the rates. You can always opt not to use the bulk rates. If you are looking for
wholesale prices please feel free to
contact us.
Typically ships in 4 to 7 days* (7 to 10 during new year season)
??
Worldwide Free Shipping
- Material: Soft Silicone
- Protects your cell phone from scratches, dust and shock
- Suitable for Samsung Galaxy Nexus i9250 / Nexus Prime To enable volume discounts on this site, use coupon code: BULKRATE during checkout. You will see a discount applied at the bottom of the shopping cart. Competitive pricing is available. Contact us for details.
| Quantity | 3+ units | 5+ units | 10+ units |
| Rate | $1.79 shipped | $1.69 shipped | $1.59 shipped |
Looking to get even more?
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Saturday, February 25, 2012
Obama says US will keep up pressure on Syria's Assad to stop 'slaughter' of civilians (Star Tribune)
Iran has expanded sensitive nuclear work: U.N. agency (Reuters)
[unable to retrieve full-text content]Reuters - Iran has sharply stepped up its controversial uranium enrichment drive, the U.N. nuclear agency said on Friday in a report that will further inflame Israeli fears the Islamic Republic is pushing ahead with atomic bomb plans.
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Friday, February 24, 2012
Dolphin Browser HD 7.3 (for Android)
If you're looking for an excellent alternative to the stock Android browser, Dolphin Browser HD 7.3 (free) is your app. It's not the fastest, but the latest version retains its Editors' Choice?designation for bringing together the most complete collection of thoughtful features in a mobile browser, without compromising on performance. Version 7 massively improves upon last year's version 5 by adding multi-device sync and a slick new RSS reader. Dolphin also carries your basic features like Flash support and Add-ons, while improving its killer feature: customizable gestures.
So if you're fishing for the UI sensibilities of?Firefox 10 (free, 2.5 stars) and the multimedia aptitude of?Opera Mobile 11?(free, 3.5 stars), reel in?Editors' Choice Dolphin Browser HD 7.3.
Dress for the Occasion
For those accustomed to the stock Android browser, Dolphin is a fluid transition. Users can access everything from bookmarks to browsing history by clicking the phone's Menu button. Moreover, Dolphin mimics Firefox: swiping in from the left reveals a Bookmarks drawer; swiping from the right unveils Add-ons and Themes, should you care to dress your browser for holidays?be it Christmas or Halloween.
The latest version freshens up an already crisp interface. Contextual menus are backlit with fluorescent green. The left sidebar gains a "Quick Access" drawer for key functions (such as Settings), a search button, and single-click bookmarking. The right panel loses Settings, but makes room for a visual tabs button. And every time you open a new tab, Dolphin now uses Speed Dial, Opera's visual bookmarking system, to automatically populate it with your favorite websites.
Add-ons make customizations more meaningful, bringing LastPass, Web to PDF, and Amazon Search into your mobile browser. The selection isn't expansive, but there's utility to be gained. While Dolphin matches Firefox step-for-step when it comes to Add-ons, it's a sloth when it comes to syncing. Dolphin Connect lets you sync bookmarks and custom gestures across all your Android tablets and smartphones. Syncing with iOS devices is on its way, Dolphin promises.??
Meaningful Gestures
One of Dolphin's cleverest features is so obvious that it seems like it ought to be standard fare for any mobile browser. Gestures lets you draw symbols to perform commonly used actions. You click the Gesture button, pinned to either the bottom left or right-hand corners of the screen?for left and right-handed users, I'm presuming?to reserve the screen for your Gesture. For example, to refresh a webpage, draw a circle. To open a new tab, an N. In addition to eight preloaded gestures, you can even create your own Gesture: I used a B to open bookmarks.
Sleek Mobile RSS Feed
I thought Dolphin's new Webzine feature would be superfluous, but it's now the first thing I open after launching Dolphin. Webzine aggregates online publications onto one page, in a series of thumbnails. Tap a thumbnail to scroll through the publication's news feed, which displays titles and summaries in boxes. Tap a box to open the original article in a new page. Webzine supports hundreds of titles like The New York Times, Cosmopolitan, and TechCrunch. Webzine's interface is very clean, with ample white space to help you scan articles quickly.?
Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/Bf6frWVTUyc/0,2817,2383132,00.asp
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Thursday, February 23, 2012
Bankruptcy Legal Alternatives ? Should really I Go For Bankruptcy ...
Bankruptcy and debt settlement- each in the options closely confer to the guidelines offered by federal department of finance. Debt has develop into one in the most important concerns around the globe. Right after the recession of 2009, the economic climate in the globe was just stuck up using the vicious cycle. There were no new investments produced by the investors and finance organizations. In such condition, the folks were stunned to face the economic barriers and they were searching for a dependable solution to manage their debts. That?s why, the associated folks produced some major alterations in the financial terms to help the customers out of this circumstance.
Debt settlement is all about minimizing the amount of debt properly without any legal involvements. Debt settlement came up with other ideas like debt consolidation, debt management and debt relief. These were all introduced by the financing organizations, government financial institutions to help out their buyers. The folks were all about to file bankruptcy when these lovely ideas and techniques were introduced. Bankruptcy can get rid of debt legally, but, it has numerous negative effects like demarcation in the financial report, ineligibility in any future financing association and all these. Apart from them, the investors were also stopped from claiming income from the bankrupt buyers.
Debt relief and management entirely depend on the unofficial negotiation using the financers and investors. The debtors, i.e. their buyers directly negotiate with them and finally an amount is fixed. The amount is fixed thinking of the applications from the debtors. That?s why, they ought to speak using the financial authorities to convince them about the debts. If they?re able to present the issue with each of the potentials and show their potencies about filing bankruptcy, they?re able to unquestionably cut down down the amount of debt instantly. So, negotiation power is actually a incredibly critical element to get your debt settled properly and speedily.
When you have no other options left and already attempted using the debt settlement, you ought to file bankruptcy. But, ahead of that, you ought to keep attempting using the other options for a greater turn around. There are lots of folks harassed because of lack of expertise and expertise at financial negotiation. They?re able to unquestionably ask for extra expert assistance to deal with those things. If you are normally in touch using the financial states, you need to have heard about the debt negotiation organizations. These organizations are providing fantastic support to resolve the debt concerns. But, although deciding on them, ensure that, you have selected a dependable one.
If you are more than $10,000 in unsecured debt it would be wise to make contact with a debt settlement company although conditions are so favorable. A legitimate debt settlement company will probably be in a position to get rid of 60% of one?s unsecured debt on typical. You will discover now on the web services that could compare debt settlement organizations for customers and supply a top rated performing company in their region. To locate a top rated performing debt settlement company within your region have a look at the link beneath.
Free but Authorized Sources Covered by the Main Bankruptcy?s FAQ Related to the Careeras a Bankruptcy Attorney. Visit Us Now for Free!
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Seriously, Do You Consider Being Courageous A Key Leadership ...
If you serious expect to be a leader, an expert in leadership strategies, you too must have courage. Leadership means taking risks, hazards you need to be content to accept before others will look on you as their leader.
To be a leader means you must be intrepid and have the fortitude needed to execute your assignments, those you commit to for your fans especially, regardless of what.
The one characteristic requested of every single leader and of for every proponent to consider when asking the question what are leadership skills, is typically unspoken. It isn't written down anywhere and yet we all look for it in those would lead us.
Does that person do what they exclaimed they would do, or not. When a leader says they'll do some they do it, they have the bravery of their commitment and their convictions to follow up on their promise.
Isn?t it fascinating that when a leader does what they guaranteed each time but once. We?ll always remember that one time when they failed to measure up to our expectations, and our eagerness to trust them, believe in them, and follow them is damaged for good.
There might be reasons, things they could not control, or they misunderstood the scope of the promise they made. But we do not really care we have lost faith in their leadership and they have lost face with us. We will never consider them seriously again, they don't have the courage we though they'd when we signed on.
Leaders must not ever hesitate at the sight of obstructions. They must not become muddled in the shadow of adversity.
Those who aspire to master leadership strategies must know that they have chosen a lonesome road. Solitude is inherit in the role of leader. There's also going to be times of great despair, of rejection, and even scorn.
As leaders they know that kind of thing incorporates the territory and they've got to be prepared to address it.
Leaders must show their courage by acting with confidence. They must persist during periods of uncertainly, challenges, and even danger. They have got to be able to excel in the troublesome times as well as in the great times. You do not have to be a leader when the current is moving in the right direction and you have got a boat full of resources. It?s when times are troublesome that leaders lead.
Leaders have a need to win. Wish to win is a critical quality of leadership all successful leaders must have inside them. If somebody does not feel that desire to win inside them ? they won't be true leaders. Their weakness, and that is what a scarcity of desire to win interprets to in the marketplace, will destroy their leadership.
Leaders whose want fuels their dedication to succeed are crucial to your organization?s success. By the same law pretenders, people whose position gives then the outward trappings of leadership but who are feeble, without the staying power of leaders, are cursed to infect their enterprise at some point.
Leadership strategies is finding and making opportunities and meeting challenges others have not addressed. It is motivating your folk, making informed, difficult choices for your company, and accepting responsibility for the consequences of your actions.
Leadership strategies needs replying to crisis with creativity, delivering creativeness in management, and demonstrating pliability in the field.
And leadership strategies is a state of mind which enables an individual to take responsibility of not only him or herself but of others, the whole organization and society as well.
The question, are you a genuine leader? Have you got the staying power to resist the challenges, the courage to do the risks , and the need to win?
For your sake and that of your fans, I hope so.
Your leadership strategy, developed with the tricks of your staff, your coachs and your peers will define your future and that of your family. Often business training courses help everyone answer the what are leadership skills query, offering the perfect vehicle for leadership development, not as there is anything new but because the ideas are being presented by outsiders. This is likely to avoid ego clashes and result in faster acceptance of what they most likely already know.
Leon Edward helps people in Personal and Career Growth, leadership Development, Goal Setting, Success, Motivation, Self-Improvement, Happiness, Memory Improvement, Stress Reduction and more through his articles, blog posts and special reports . Join Leon Edwards Awesome Success Free, Get his personal success, development and growth weekly newsletter as well as success classics and tips on attracting success and wealth. Visit his Success-Leadership Library, Articles at http://www.AwesomeSuccess.org Leon Edward also helps people improve IQ, focus, memory, concentration, creativity, speed reading, public speaking , time management and reducing stress. Download his IQ Mind Brain Memory Self-Help library at his website http://www.IQMindBrainLibrary.comLeon Edward helps people improve in Leadership Development, Goal Setting, Success, Motivation, Self-Improvement, Happiness, Memory Improvement, Stress Reduction and more through his articles, blog posts and special reports . Join Leon Edwards Awesome Success Free, Get his personal development training, success and growth weekly newsletter as well as success classics and tips on attracting success and wealth. Visit his Success-Leadership Library, Articles at http://www.AwesomeSuccess.orgYou may also be interested in
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Wednesday, February 22, 2012
Benefits associated with Wearing Great Yoga Pants For Females ...
New Health And Fitness.Org - Health Information You Can Use
Many people are getting a problem exercising yoga only because they aren?t being dressed in the right type of yoga pants. The proper kind of yoga exercise pants for females is essential to the total advantage of the particular yoga exercise exercise. Before we can know the affect of the clothing apparel, it is important to know the concept behind yoga exercise.
Yoga, in the literal sense, is a kind of deep breathing that is made of a system of exercises to support manage the entire body, thoughts and the soul of the human being. The way for an individual to succeed in the perfect condition of religious calmness is through the practice of yoga exercise that greatly calms through the path of knowledge, actions as well as devotion. The goal of yoga would be to unite the body using the mind, and then to unite the mind using the soul. What yoga aims to do is to pave the way for an individual to make him/her attain a life which is both joyous and also cheerful.
The concept of yoga exercise as well as meditation helps greatly within achieving the aim regarding unity : that means the unity of mind, entire body as well as nature. With yoga exercise practices, the individual has the capacity to reach the state of endless bliss, and also he/she will also be able to attain that particular unity along with divinity.
When purchasing your first yoga exercise pants, it may be ideal that you select the right low cost yoga exercise pants accessible. The particular cheapness of the yoga pants does not necessarily must give up the quality. Instead, it simply means that you?ll be able to get the ones which will fit your budget.
If you are looking to purchase yoga pants visit online website www.electric-yoga.com where you come across several types of yoga pants in different colour and also sizes.One reason why men and women buy affordable yoga exercise pants for women is because low cost pants are simpler to replace than the normal ones.
Looking to find the best deal on yoga pants, then visit www.electric-yoga.com to find the best advice on yoga tops for you.
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Tuesday, February 21, 2012
Telomere failure, telomerase activation drive prostate cancer progression
![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 20-Feb-2012[ | E-mail |
Share ] Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Study employs mouse models, genomic analysis of human tumors, to identify genetic changes
HOUSTON - Genomic instability caused by an erosion of the protective caps on chromosomes, followed by activation of an enzyme that reinforces those caps, allows malignant cells to evade destruction and acquire more deadly characteristics, researchers report in an Online Now article at the journal Cell.
In a strain of mice engineered to develop prostate cancer, all mice that went through this two-step process developed lethal cancer and 25 percent had the disease spread to the spine. Two groups of mice that avoided this cycle developed only precancerous lesions or localized prostate cancer.
A comparative analysis of genetic changes in the metastatic mouse tumors and those found in metastatic human prostate cancer identified the Smad4 gene as a driver in bone metastasis. Fourteen other genes were found to be associated with human prostate cancer prognosis.
The research focused on telomeres - repeat nucleotide sequences at the tips of chromosomes that prevent genomic damage during cell division. Telomeres shorten with each cell division, eventually permitting genomic instability in the cells that normally causes these abnormal cells to die.
In cancer the enzyme telomerase becomes activated and lengthens telomeres, preserving damaged cells to survive and reproduce. Telomerase is inactive in normal cells.
Telomerase activation confers new strengths on tumors
"These in vivo mouse studies, together with human and mouse prostate cancer genomic data, provide evidence that telomere dysfunction plays a critical role in prostate cancer initiation and progression," said co-senior author Lynda Chin, M.D., professor and chair of The University of Texas MD Anderson Cancer Center's Department of Genomic Medicine.
"Our studies also show that telomerase activation after genomic instability caused by telomere dysfunction enables evolving cancers to progress and acquire new biological properties, including central features of advanced human prostate cancer," Chin said.
Chin, co-senior author and MD Anderson President Ronald DePinho, M.D., and colleagues conducted this research while at Dana-Farber Cancer Institute in Boston.
Telomere dysfunction, fired-up telomerase, cause bone metastasis
The team took a strain of mice with both the p53 and pten tumor-suppressing genes knocked out that normally develop nonmetastatic prostate cancer and engineered some to express telomerase. They were cross-bred for several generations.
- Control mice with intact telomeres (either wild-type mice or those with telomerase expressed) avoided the genomic instability caused by telomere shortening. All of these mice developed locally invasive, nonmetastatic prostate cancer.
- Mice without telomerase were subject to telomere dysfunction and genetic changes and developed precancerous high-grade prostate intraepithelial neoplasia (HPIN) but 60 percent of them did not progress to prostate cancer. Signs of programmed cell death triggered by genetic abnormalities abounded in this group.
- Mice subject to telomere dysfunction, genomic instability and telomerase activation also developed HPIN but then progressed to lethal bulky tumors, with 5 of 20 developing spinal metastases that were not seen in the genome-stable mice.
"Not only did telomerase reactivation bypass the cancer progression block that arises with telomere dysfunction, it also conferred a new property - bone metastasis - that was not seen in tumors that did not go through telomere dysfunction followed by telomerase reactivation," said first author Zhihu Ding, Ph.D., formerly of Dana-Farber and now with Sanofi-Aventis, Inc.
"This provides the first genetic evidence that telomerase reactivation and genome stabilization are necessary to drive full malignant progression in epithelial cancers," Ding said.
Aligning genetic alterations in mice and humans
Chin, Ding and colleagues analyzed gene copy number aberrations - genes deleted or amplified - in 18 advanced tumors from the mice and 194 human prostate tumors.
They found 22 of the 94 copy number alterations involving deletion or amplification of 741 genes identified in mice were similar to those found in humans. A series of analyses of changes found in bone metastases pointed to deletions of the Smad4 tumor-suppressor gene, which regulates the transforming growth factor beta (TGF-) pathway.
The team took this finding back to the mouse model with tumor suppressors p53 and pten knocked out. These mice don't develop bone metastasis, but when the researchers also knocked out Smad4, more aggressive tumors developed, including bone metastasis in three of 24 mice.
Genes prognostic for human prostate cancer
Next, they looked at 14 genes in nine molecular pathways found to be enriched in bone metastasis to see if they were prognostic for recurrence (as measured by PSA levels after surgery) among 140 prostate cancer patients.
The 14-gene set was significantly prognostic of biochemical recurrence, providing evidence of their biological relevance to human prostate cancer, but the researchers noted that their individual contributions and mechanisms of action will require further research.
"Overall, our findings validate the integrative approach of employing genotype-phenotype correlations found in the mouse model with the power of genomic and bioinformatic analyses to discover and explain molecular mechanisms that drive prostate cancer," said co-first author Chang-Jiun Wu, Ph.D., a postdoctoral fellow in MD Anderson's Department of Genomic Medicine.
###
Co-authors with Chin, DePinho, Ding and Wu are Alexei Protopopov, Ph.D., Jianhua Zhang, Ph.D., and Liren Li, M.D., Ph.D., of MD Anderson's Department of Genomic Medicine; Guocan Wang, Ph.D., Xin Lu, Ph.D., Jian Hu, Ph.D., Wei Wang, Ph.D., Shan Jiang, Ph.D., and Yaoqi Alan Wang, Ph.D., of MD Anderson's Department of Cancer Biology; Maria Kost-Alimova, Chin, Protopopov and Zhang are with MD Anderson's Institute for Applied Cancer Science. All were formerly of Dana-Farber Cancer Institute. Also Mariela Jaskelioff, Ph.D., Elena Ivanova, Ph.D., Gerald Chu, M.D., Ph.D., Emma Labrot, Yonghong Xiao, Ph.D., Hailei Zhang, Jingfang Zhang, Boyi Gan, Ph.D., and Samuel Perry, all of the Department of Medical Oncology at Dana-Farber Cancer Institute.
This research was funded by grants from the National Cancer Institute, the Prostate Cancer Foundation, the U.S. Department of Defense, the Damon Runyon Cancer Research Foundation, the Multiple Myeloma Research Foundation, an American Cancer Society and the Robert A. and Renee E. Belfer Foundation.
About MD Anderson
The University of Texas MD Anderson Cancer Center in Houston ranks as one of the world's most respected centers focused on cancer patient care, research, education and prevention. MD Anderson is one of only 40 comprehensive cancer centers designated by the National Cancer Institute. For eight of the past 10 years, including 2011, MD Anderson has ranked No. 1 in cancer care in "Best Hospitals," a survey published annually in U.S. News & World Report.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 20-Feb-2012[ | E-mail |
Share ] Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Study employs mouse models, genomic analysis of human tumors, to identify genetic changes
HOUSTON - Genomic instability caused by an erosion of the protective caps on chromosomes, followed by activation of an enzyme that reinforces those caps, allows malignant cells to evade destruction and acquire more deadly characteristics, researchers report in an Online Now article at the journal Cell.
In a strain of mice engineered to develop prostate cancer, all mice that went through this two-step process developed lethal cancer and 25 percent had the disease spread to the spine. Two groups of mice that avoided this cycle developed only precancerous lesions or localized prostate cancer.
A comparative analysis of genetic changes in the metastatic mouse tumors and those found in metastatic human prostate cancer identified the Smad4 gene as a driver in bone metastasis. Fourteen other genes were found to be associated with human prostate cancer prognosis.
The research focused on telomeres - repeat nucleotide sequences at the tips of chromosomes that prevent genomic damage during cell division. Telomeres shorten with each cell division, eventually permitting genomic instability in the cells that normally causes these abnormal cells to die.
In cancer the enzyme telomerase becomes activated and lengthens telomeres, preserving damaged cells to survive and reproduce. Telomerase is inactive in normal cells.
Telomerase activation confers new strengths on tumors
"These in vivo mouse studies, together with human and mouse prostate cancer genomic data, provide evidence that telomere dysfunction plays a critical role in prostate cancer initiation and progression," said co-senior author Lynda Chin, M.D., professor and chair of The University of Texas MD Anderson Cancer Center's Department of Genomic Medicine.
"Our studies also show that telomerase activation after genomic instability caused by telomere dysfunction enables evolving cancers to progress and acquire new biological properties, including central features of advanced human prostate cancer," Chin said.
Chin, co-senior author and MD Anderson President Ronald DePinho, M.D., and colleagues conducted this research while at Dana-Farber Cancer Institute in Boston.
Telomere dysfunction, fired-up telomerase, cause bone metastasis
The team took a strain of mice with both the p53 and pten tumor-suppressing genes knocked out that normally develop nonmetastatic prostate cancer and engineered some to express telomerase. They were cross-bred for several generations.
- Control mice with intact telomeres (either wild-type mice or those with telomerase expressed) avoided the genomic instability caused by telomere shortening. All of these mice developed locally invasive, nonmetastatic prostate cancer.
- Mice without telomerase were subject to telomere dysfunction and genetic changes and developed precancerous high-grade prostate intraepithelial neoplasia (HPIN) but 60 percent of them did not progress to prostate cancer. Signs of programmed cell death triggered by genetic abnormalities abounded in this group.
- Mice subject to telomere dysfunction, genomic instability and telomerase activation also developed HPIN but then progressed to lethal bulky tumors, with 5 of 20 developing spinal metastases that were not seen in the genome-stable mice.
"Not only did telomerase reactivation bypass the cancer progression block that arises with telomere dysfunction, it also conferred a new property - bone metastasis - that was not seen in tumors that did not go through telomere dysfunction followed by telomerase reactivation," said first author Zhihu Ding, Ph.D., formerly of Dana-Farber and now with Sanofi-Aventis, Inc.
"This provides the first genetic evidence that telomerase reactivation and genome stabilization are necessary to drive full malignant progression in epithelial cancers," Ding said.
Aligning genetic alterations in mice and humans
Chin, Ding and colleagues analyzed gene copy number aberrations - genes deleted or amplified - in 18 advanced tumors from the mice and 194 human prostate tumors.
They found 22 of the 94 copy number alterations involving deletion or amplification of 741 genes identified in mice were similar to those found in humans. A series of analyses of changes found in bone metastases pointed to deletions of the Smad4 tumor-suppressor gene, which regulates the transforming growth factor beta (TGF-) pathway.
The team took this finding back to the mouse model with tumor suppressors p53 and pten knocked out. These mice don't develop bone metastasis, but when the researchers also knocked out Smad4, more aggressive tumors developed, including bone metastasis in three of 24 mice.
Genes prognostic for human prostate cancer
Next, they looked at 14 genes in nine molecular pathways found to be enriched in bone metastasis to see if they were prognostic for recurrence (as measured by PSA levels after surgery) among 140 prostate cancer patients.
The 14-gene set was significantly prognostic of biochemical recurrence, providing evidence of their biological relevance to human prostate cancer, but the researchers noted that their individual contributions and mechanisms of action will require further research.
"Overall, our findings validate the integrative approach of employing genotype-phenotype correlations found in the mouse model with the power of genomic and bioinformatic analyses to discover and explain molecular mechanisms that drive prostate cancer," said co-first author Chang-Jiun Wu, Ph.D., a postdoctoral fellow in MD Anderson's Department of Genomic Medicine.
###
Co-authors with Chin, DePinho, Ding and Wu are Alexei Protopopov, Ph.D., Jianhua Zhang, Ph.D., and Liren Li, M.D., Ph.D., of MD Anderson's Department of Genomic Medicine; Guocan Wang, Ph.D., Xin Lu, Ph.D., Jian Hu, Ph.D., Wei Wang, Ph.D., Shan Jiang, Ph.D., and Yaoqi Alan Wang, Ph.D., of MD Anderson's Department of Cancer Biology; Maria Kost-Alimova, Chin, Protopopov and Zhang are with MD Anderson's Institute for Applied Cancer Science. All were formerly of Dana-Farber Cancer Institute. Also Mariela Jaskelioff, Ph.D., Elena Ivanova, Ph.D., Gerald Chu, M.D., Ph.D., Emma Labrot, Yonghong Xiao, Ph.D., Hailei Zhang, Jingfang Zhang, Boyi Gan, Ph.D., and Samuel Perry, all of the Department of Medical Oncology at Dana-Farber Cancer Institute.
This research was funded by grants from the National Cancer Institute, the Prostate Cancer Foundation, the U.S. Department of Defense, the Damon Runyon Cancer Research Foundation, the Multiple Myeloma Research Foundation, an American Cancer Society and the Robert A. and Renee E. Belfer Foundation.
About MD Anderson
The University of Texas MD Anderson Cancer Center in Houston ranks as one of the world's most respected centers focused on cancer patient care, research, education and prevention. MD Anderson is one of only 40 comprehensive cancer centers designated by the National Cancer Institute. For eight of the past 10 years, including 2011, MD Anderson has ranked No. 1 in cancer care in "Best Hospitals," a survey published annually in U.S. News & World Report.
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Source: http://www.eurekalert.org/pub_releases/2012-02/uotm-tft022012.php
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Flood dislodges land mines, closing Chile highway (AP)
[unable to retrieve full-text content]AP - Chilean authorities say flooding from heavy rains dislodged anti-personnel and anti-tank mines, floating two of the explosive devices onto the Pan-American Highway near the border with Peru.
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Monday, February 20, 2012
Get In Shape With A Personal Trainer NJ | New Health and Fitness
New Health And Fitness.Org - Health Information You Can Use
Everybody gets to that point where they realize that they have to do something about their weight and their general health and fitness. Unfortunately, not many people have the discipline to do this on their own, hence the need for a personal trainer NJ. With help, everybody can live a healthier life.
Being fit is something that everybody would like to be for that hiking trip that is coming up very soon. Get to a professional that can help on how to be fit and to work out a program that will be well suited to get fit fast. Be proud and tell everybody the plan of action to feel good again and walk with a jump in your step and feel young again.
Get help from a professional to show the ropes. Do not overdo it, start at a point and work slowly towards your goal of getting fit. The body needs to adapt with the new exercises that it is not used to. By eating healthy it can do wonders for the body to adapt to a new lifestyle that includes exercise and enjoyable activities.
People cannot go through life without a bit of hard work. The problem of negativity will interfere but to stay determined the lack of discipline will disappear and the positive attitude will kick in. This is why a personal advisor is so important. He can help with motivation issues.
Go to the local gym or health clinic and ask them for references to professional help. There are a lot of resources to seek help and assistance, just ask around be amazed on how many information you will be receiving.
A personal trainer NJ is the best solution for many people that simply do not have the confidence to start a whole new regime on their own. These professional understand the pressures of modern life and they are normally able to work out a program that will suit their client.
Find out more about personal trainer NJ at our website
Source: http://newhealthandfitness.org/2012/02/20/get-in-shape-with-a-personal-trainer-nj/
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Grayson & Grayson LA Personal Injury Lawyers to Offer Legal ...
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Grayson & Grayson LA Personal Injury Lawyers to Offer Legal Assistance to Victims of Hit and Run CasesLos Angeles, CA, February 16, 2012 ?(PR.com)? California drivers under the state?s law are obligated to stay at the scene of an accident they have caused or been involved in and cannot run from the scene of accident or when they have hit an object, property or person. The accident often times causes personal injury which is a compensable offense and the driver is legally compelled to stop and exchange insurance and identifying information for and recompense the loss occurred due to his or her negligence. Since injuries caused as a result of a hit and run come under personal injury litigation, Grayson & Grayson (http://www.markgraysonlaw.com/) personal injury lawyers will now be offering their legal expertise to assist victims of hit and run cases get just compensation.
Hit and run cases may result in permanent damages or serious injuries to a person and if the driver flees from the scene, he or she can be criminally charged with a hit and run. The charges could very well go up to be of felony or misdemeanor in case of very serious accidents and incarceration is also possible. However, it?s not easy to identify culprits of hit and run cases as tracing negligent drivers is not easy. Victims have to rely on witness accounts and other clues to find the driver and press charges.
Mark Grayson from Grayson & Grayson law firm emphasized the need to pursue hit and run cases legally and commented, ?A hit and run case is among the more complicated injury scenarios. The victims not only have to bear the trauma of injuries but also go through the stressful search for the perpetrator. If you?ve been the victim of a hit and run, you should contact the local Law Enforcement Agency immediately, and definitely within 24 hours of the accident. They can be extremely helpful in tracking down the driver who fled the scene and a formal accident report filed with law enforcement may be required in the event there may be an uninsured motorist claim. There may be extreme damage done to property or an individual may suffer serious injuries as a result of the accident. In either scenarios the repercussions have to be borne by the one on the receiving end of damages. That?s why it?s important that once the victim has identified the responsible driver that caused harm perfected an uninsured motorist claim, he or she timely files a claim and demands just compensation.?
Hit and run cases should be handled by professional LA personal injury lawyers. Personal injury attorneys are qualified to take up motor vehicle accident cases, car wrecks as a result of negligent or wrongful operation of a vehicle where drivers leave the scene of accident.
?Lawyers representing hit and run culprits try really hard to get their clients acquitted of felony charges and get them reduced to misdemeanor, the sentence for which often times lets the negligent driver get away with community service and a small fine. Experienced personal injury lawyers on the other hand will fight for the just claim and ensure that victims have been fully compensated for the loss suffered by them.?
Grayson & Grayson offers information about motor vehicle accidents on their website at: http://www.markgraysonlaw.com/expertise-areas/motorvehicle-accidents/.
LA personal injury lawyers at Grayson & Grayson also handle medical malpractice cases, dog bite cases, automobile accidents, wrongful death cases and other claims that fall under the California personal injury litigation.
About Grayson and Grayson
The firm was founded by the father-son duo ? Saul and Mark Grayson in 1984 and brings over 30 years of experience in Personal Injury Law trials. The Los Angeles personal injury law firm has expertise in the field of personal injury and accidents including automobile, truck, bicycle, motorcycle, uninsured motorist, construction, dog bites, slip and fall, and pedestrian accidents.
In addition, Grayson & Grayson Law Firm also handles medical, hospital and pharmaceutical malpractice claims, legal malpractice claims, liability and wrongful death claims.
For More information, Contact:
Grayson and Grayson
10880 Wilshire Blvd. #1840
Los Angeles
CA 90024
Phone: 310-474-8889
Fax: 310-470-8008
Email: mgesq@aol.com
Website: http://www.markgraysonlaw.com/
Blog: http://www.markgraysonlaw.com/blog
###
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Sunday, February 19, 2012
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Source: http://www.lyghdc.com/news/today/Q7jAXIJJPt.html
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Saturday, February 18, 2012
This Week's Top Web Comedy Video: Student Loan STDs [Video]
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The Many Advantages Of Web Design Lehigh Valley | Internet ...
It is no longer necessary to explain to entrepreneurs why it is that they need a website or several websites. The Internet has become the largest trading platform in the world and the competition is extremely fierce. In order to partake of this massive market, the services of web design Lehigh Valley specialists are necessary.
Great care should be taken that websites are easy to use and that all links work properly. Modern Internet users are fickle and they simply will not abide poorly designed sites that are not clearly laid out. Information should be easily obtainable and links should be clearly labeled. Few things are as frustrating as fumbling around a site looking for information.
Another important feature of successful sites is that they are always fresh and new. Visitors only frequent sites that are up to date and that offer new information, products and special offers on a regular basis. There are many examples of sites that offer special deals that have expired long ago but these sites inevitably cause a poor reflection upon the owner and is a liability rather than an asset.
When selecting a specialist to develop a site, it is vital to choose somebody that understands business. There are many pretty sites that simply fail because the initial design was poorly done. The focus should not be on the appearance of the site, but rather on the function it is supposed to fulfill.
Because the competition is so fierce, it is very important to take steps to increase the rankings of a website. If this is not done, the site will never come to the attention of consumers that typically use search engines to find the information, products or services that they are after. Banner adverts, publications and links from other sites can be used to achieve this.
In web design Lehigh Valley experts have proven themselves. They are able to create sites that are easy to use, that look attractive and that provide for regular updating. Many specialists are also able to advise on ways in which the site can be promoted. web design lehigh valley
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Friday, February 17, 2012
WriteAndCorrect.com ? House Wellness & Health and fitness Diet ...
There are stuff which will have an effect on the individuals capability to be able to drop fat and you ought to be sensitive to that particular within your companion in the event that they begins to gain weight.
No matter how cautious the person is of their weight, presently there are problems that may cause weight gain in order to happen anyhow. Being delicate to your partner of their weight gain can make it all much easier for them to drop the load. Remain positive and also encourage your current partner by your own actions rather connected with poking fun in their own pounds problem. For instance, rather associated with telling your own partner just how disgusting they are starting to look, request him/her to consider the stroll along with you. Rather involving recommending that restaurant which has all the unhealthy meals that you companion adores, suggest the Chinese language diner instead.
There is do not need be insensitive with regards to your lover?s weight gain. It can cause problems in the relationship that will not shortly be fixed. In simple fact, it can be the greatest demise of the romantic relationship. Treat your own companion with the exact same respect once they gain weight when you might when at the weight anyone view because suitable. There is a chance that the shoe may be on the some other feet. In what you15479 feel if it was you actually?
You could be a help or even the hindrance to whether your partner is able to shed fat. Why would you make somebody which you in order to like feel bad related to on their own. Getting insensitive to weight gain is among the easiest ways to tear down an individuals self-pride. Should you improve their own self-pride, you happen to be doing yourself a good injustice due to the fact which person can ultimately get into such the deep layer that you might never ever be able in order to deliver them out of it once again.
Your partner deserves to be treated with respect regardless of how much they will consider. In case you have an issue along with your lover?s weight, it all is ok in order to encourage them. What exactly is not really ok would be to treat all of them poorly because of the weight gain. A person obtain everything you sow. Be sure you obtain the very best of your romantic relationship even though your partner gains weight.
The fight to put on weight can be every bit while irritating as the fight to get rid of weight, perhaps specially.
The fight to put on weight started just simply previous in order to getting into high school when on the summertime We obtained numerous inches in height. On 5?7, We hardly tipped the weighing scales with 82 lbs.
I increased way up however not out there regardless of how much foods I devoured. Whenever I obtained pregnant from age group 21 years old, I idea sure that I had created group on some pounds. We do but it was a temporary increase. After having kids, I lost my weight within a day time and kept the hospital wearing my regular clothes.
On twenty two, We joined up with the health and fitness program and was place on the weight gain diet plan. I occurred like a just underweight lady within the team. Each day on entering the actual fitness center, we were weighed. For that overweight females a bell might sound and everyone would certainly cheer when they lost a pound. Being the only underweight lady, the actual woman might every and each and every time wedding ring her bells as well as that they had all start to perk till actuality set in and She?d say, ?oops?. It was embarrassing to say minimal. We shortly quit the gym since it all seemed the actual strenuous exercise only served to boost my already extremely fast metabolism burning off all of the extra calories from fat.
Go through more how to gain weight fast on our blog!
Source: http://writeandcorrect.com/house-wellness-health-and-fitness-diet-programs-weight-problems/
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Stepbrother charged with sexual abuse of Wis. teen
Mike Vega points to the area of sidewalk in Madison, Wis., Wednesday, Feb. 15, 2012, where he discovered a starving 15-year-old after she escaped from her abusive father and stepmother last week. The severely malnourished teenager had been forced to stay in an unfinished basement for years and an alarm would sound if she went upstairs, police records say. The teen told authorities she ate what she could find in the garbage and on the floor of her father and stepmother's Madison home. Sometimes she was made to eat her feces and drink her own urine, according to a police affidavit. (AP Photo/Todd Richmond)
Mike Vega points to the area of sidewalk in Madison, Wis., Wednesday, Feb. 15, 2012, where he discovered a starving 15-year-old after she escaped from her abusive father and stepmother last week. The severely malnourished teenager had been forced to stay in an unfinished basement for years and an alarm would sound if she went upstairs, police records say. The teen told authorities she ate what she could find in the garbage and on the floor of her father and stepmother's Madison home. Sometimes she was made to eat her feces and drink her own urine, according to a police affidavit. (AP Photo/Todd Richmond)
MADISON, Wis. (AP) ? Prosecutors on Thursday charged the stepbrother of a severely malnourished Wisconsin teen with repeatedly sexually assaulting her beginning around her 10th birthday, in the same year she claims her father and stepmother began confining her to the basement.
Dane County prosecutors also charged the girl's father, 40, and stepmother, 42, with child abuse and first-degree reckless endangerment, which are felonies, as well as a misdemeanor count of neglecting a child.
The couple and the girl's stepbrother, 18, appeared in a Madison courtroom Thursday for an initial hearing.
Prosecutors allege the stepbrother first sexually assaulted the girl in December 2006, which was the month she turned 10, and again from February 2009 through February 2010. He is charged with first-degree sexual assault of a child without great bodily harm, second-degree sexual assault of a child and child abuse ? all felonies.
Cash bail between $22,500 and $30,000 was set for each of the three defendants. The Associated Press is not naming the defendants to protect the girl's identity.
A woman believed to be the stepmother's sister declined to comment Wednesday when reached by phone and did not immediately respond to a phone message left Thursday at her home.
The girl has been receiving medical care and is in protective custody, police said Thursday.
The girl, who was 70 pounds when found, gained 17 pounds as of Wednesday, the complaint said.
At least two neighbors said they had called child protective services after seeing the girl rummaging through the garbage for food or being berated by the family.
According to the Department of Children and Families, there had been 10 reports of suspected neglect, sexual abuse or physical since 2006, three of which remain pending. Those three include a Feb. 6 report ? the day a passing motorist spotted the girl walking barefoot and wearing thin pajamas.
The department released few details, citing legal reasons.
Of the seven others, six were unsubstantiated or didn't meet the legal definition of abuse or neglect. The department says a May 1997 report of physical abuse was substantiated but didn't note what more happened.
According to the complaint, the girl's stepbrother tried unsuccessfully to have intercourse with her once and he forced her to perform oral sex on him more than 10 times.
She said she told her father and stepmother that the stepbrother was doing "sexual things" to her in 2006, but they thought she was lying. She told a school counselor, and in March 2007 a Dane County child protective services worker and a police detective met with her at the school.
The girl refused to tell them anything, however. The county worker met with her father and stepmother, but they refused to allow her or the police to speak to the stepbrother.
The county later received information that the stepbrother was sent to live with his grandfather to hide from investigators. The father and stepmother expected police to execute a search warrant at their house, so they tried to make the basement bedroom "not look like a dungeon," according to the complaint.
The girl told detectives that her stepmother was responsible for most of her injuries, saying the woman didn't want to marry her father because of her.
After she was transported to the hospital, the father told a doctor and a social worker that family members locked the girl in the basement because they were afraid she might hurt them. They even set up an alarm on the door, put bars on the basement windows and placed cameras on the kitchen pantry in case she tried to steal food.
The girl acknowledged to a detective she has wanted to kill the stepmother and has told her father and the stepbrother she wanted to cut them, but "it was only words."
The girl said she had run away before but her parents had always found her. She fled Feb. 6 because her stepmother threatened to throw her down the stairs headfirst or slit her throat for not picking up papers fast enough, the complaint said.
"I ran away this time because I just couldn't handle it anymore," she told doctors. "I thought she was going to hurt me and throw me down the stairs. I was afraid."
The girl told investigators she sometimes urinated and defecated in the basement because she didn't want to trip the alarm going upstairs or make anyone upset.
She said sometimes her stepmother and her father would make her eat her feces or drink her urine or rub them on her face.
The girl said her stepmother demanded to be called "your majesty" or "master." She said the stepmother told her father that if he wanted to marry her he had to give the girl to her and she was the girl's personal owner, the complaint said.
In a separate case, the stepbrother pleaded no contest last year to charges that he had sexual contact with a child. That criminal complaint says he acknowledged touching the breasts of his 13-year-old girlfriend but denied having sex. The girl told investigators the two had sex in her room about three times, and that he slept in her bed with her mother's knowledge.
The boy pleaded no contest in that case to second-degree sexual assault of a child and three related misdemeanor charges. He was sentenced to three years on probation.
___
Associated Press writer Carrie Antlfinger in Milwaukee contributed to this report.
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Thursday, February 16, 2012
Use outsourcing for Business to business telemarketing in Lead ...
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The principle purpose of Leads generation is for an organization to expand their market share by means of reaching your high-level decision makers of establishments involved inside of its goal industry. The majority of Lead authorities are well experienced in discovering the needs of the prospects as well as inspire your prospect?s executives to engage the telephone selling call center to help you the potential customers produce qualified leads and set appointments with all the company?s revenue teams. Outsourcing the lead process increases a new company?s product sales and income while decreasing the cost per sale bills. Outsourced Prospecting also gets rid of a challenging management process. The main reason for outsourcing techniques telemarketing providers is that telephone selling call centers add effective sales orientation plans to get the best advantages of the market. To generate leads campaigns have to be done continuously to weather conditions market trend shifts along with changes in the international market economic climate.
Lead Generation requires a exacting process of discovering prospective customers, growth of a qualified prospects list along with the launch of the rigorous phoning campaign.
The initial step in Guide is being capable to set requirements in order to identify the prospect that your client would want to have company or communicate with. Criteria are fantastic jump off points in every single campaign as it guides you as to what exactly you will need to. However, in lead generation, the client?s standards base must not be too certain or as well general to generate space to have an ever-evolving market craze.
After creating the lead criteria, a company?s marketing agent must know her or his lead origin. He must be able to identify your sources of prospects and be able to begin using these efficiently and effectively to be able to routinely build leads along with continuously update the prospects list these people currently have.
If your company determines to hire their own team of lead phone callers, they must be able to train their staff in phone social grace, identifying the prospects as well as their questions along with issues about the service being offered. Also, a firm must be ready to put up a dentist?s office specifically designed to the lead generation telemarketers. They should also device a fool-proof income script in whose pitch appears personal but still has an portion of sales and marketing integrated.
When involved in their own lead generation campaign, a business may also notice fit to acquire their own automated responder, including Live Talk, wherein prospect customers may leave query messages when they?re unavailable to call you through phone. They will often also abandon their contact information herein to ensure that you may be able to go back to them when a representative can be acquired.
When outsoucring, Lead gets to be more effective and also practical as compared to maintaining you use private personnel doing the job to suit your needs. For one, offsite lead generation telemarketing is a cost-efficient substitute for an otherwise high-priced restructuring of the office and the programs and application to be used within the campaign. Your client may simply join a month-long campaign and has the choice to terminate the alliance after the commitment or keep on the advertising campaign for a longer time.
Furthermore, the company should be able to save on the costs of training which may otherwise be shouldered through the company if they decide to put by themselves team. Outsoucring Lead Generation activities maintain their very own training crew who have been carrying out lead promotions for years and are therefore experts on the subjects of piece of software making, mobile phone etiquette and convincing tactics which will finally lead to a face-to-face appointment with a buyer?s sales representative.
In addition, telemarketing businesses provide clients with standard progress reviews to make sure that your representatives in charge of their campaign are executing according to his or her standards.
It is best to outsource sales opportunities generation has to an established business to business telemarketing call center as well as outbound telemarketing firms as these companies include the latest technology and the very best people to carry out the campaign in a very manner that clients count on from their own team.
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